This is a post-apocalyptic drama/action novel, the first of the trilogy.
A pandemic ravages the globe. The virus turns people insane, causing them to attack anyone they see. Society collapses, armed forces are overrun and soon everyone has to fend for themselves to survive.
In upstate New York, Samantha survives the initial onslaught and takes shelter in her home. After things calm down, she decides to travel across the country to find her husband who was stranded in Los Angeles. Along the way, she meets another surviver who is also traveling west. Together, they face the hell that the United States has fallen into.